Sigma-1 receptor in neurodegenerative, inflammatory, cancer and cardiometabolic diseases
Sigma-1 receptor is a multi-faceted protein that is involved in numerous physiopathological pathways. The main aim of this WG is to identify the mechanistic links between the pathogenesis of neurodegenerative, inflammatory, cancer and cardiometabolic diseases and the modulation of sigma-1 receptor activity by ligands. With the aid of the molecules/probes developed in WG1, the Action particularly address the exact molecular mechanisms and their contribution to complex neuroprotective and neurorestorative processes; develop approaches for the treatment of neuropathic or inflammatory pain; and aim at a clear understanding of sigma-1 receptor function in tumour cell growth and/or apoptosis.